{-# LANGUAGE DeriveGeneric #-} {-# LANGUAGE OverloadedStrings #-} {-# LANGUAGE StandaloneDeriving #-} {-# OPTIONS_GHC -Wno-orphans #-} -- | -- Module : TLynx.Simulate.Options -- Description : Argument parser for seq-ana -- Copyright : (c) Dominik Schrempf 2021 -- License : GPL-3.0-or-later -- -- Maintainer : dominik.schrempf@gmail.com -- Stability : unstable -- Portability : portable -- -- Creation date: Fri May 3 11:51:07 2019. module TLynx.Simulate.Options ( Process (..), SimulateArguments (..), simulateArguments, reportSimulateArguments, ) where import Data.List import Data.Maybe import ELynx.Tools import ELynx.Tree.Simulate.PointProcess (TimeSpec (..)) import Options.Applicative deriving instance Eq TimeSpec deriving instance Generic TimeSpec instance Show TimeSpec where show Random = "Random" show (Origin o) = "Condition on height of origin: " ++ show o show (Mrca m) = "Condition on height of MRCA: " ++ show m instance FromJSON TimeSpec instance ToJSON TimeSpec -- | Process to be used for simulation. data Process = BirthDeath { -- | Birth rate. bdLambda :: Double, -- | Death rate. bdMu :: Double, -- | Sampling rate. bdRho :: Maybe Double, -- | Condition on height? bdHeight :: TimeSpec } | Coalescent deriving (Eq, Show, Generic) instance FromJSON Process instance ToJSON Process reportProcess :: Process -> String reportProcess (BirthDeath l m mr ts) = intercalate "\n" [ "Model: Birth and death process", " Birth rate: " ++ show l, " Death rate: " ++ show m, " Sampling probability: " ++ maybe "1.0" show mr, " Height specification: " ++ show ts ] reportProcess Coalescent = "Model: Coalescent process" -- | Arguments need to simulate phylogenetic trees using birth and death processes. data SimulateArguments = SimulateArguments { -- | Simulated trees. argsNTrees :: Int, -- | Number of leaves. argsNLeaves :: Int, -- | Process. argsProcess :: Process, -- | Perform sub-sampling with given probability. argsSubSample :: Maybe Double, -- | Only print summary statistics? argsSumStat :: Bool, -- | Seed of NRG, random if 'Nothing'. argsSeed :: SeedOpt } deriving (Eq, Show, Generic) instance Reproducible SimulateArguments where inFiles _ = [] outSuffixes _ = [".tree"] getSeed = Just . argsSeed setSeed a s = a {argsSeed = s} parser = simulateArguments cmdName = "simulate" cmdDsc = ["Simulate phylogenetic trees using a birth and death or coalescent process."] cmdFtr = simulateFooter instance FromJSON SimulateArguments instance ToJSON SimulateArguments -- | Print useful information about the provided arguments. reportSimulateArguments :: SimulateArguments -> String reportSimulateArguments a = intercalate "\n" [ "Number of simulated trees: " ++ show (argsNTrees a), "Number of leaves per tree: " ++ show (argsNLeaves a), reportProcess (argsProcess a), "Perform sub-sampling: " ++ ssStr, "Summary statistics only: " ++ show (argsSumStat a) ] where ssStr = case argsSubSample a of Nothing -> "No" Just p -> "Yes, with probability " ++ show p -- | Command line parser. simulateArguments :: Parser SimulateArguments simulateArguments = SimulateArguments <$> nTreeOpt <*> nLeavesOpt <*> process <*> subSampleOpt <*> sumStatOpt <*> seedOpt nTreeOpt :: Parser Int nTreeOpt = option auto $ long "nTrees" <> short 't' <> metavar "INT" <> help "Number of trees" nLeavesOpt :: Parser Int nLeavesOpt = option auto $ long "nLeaves" <> short 'n' <> metavar "INT" <> help "Number of leaves per tree" lambdaOpt :: Parser Double lambdaOpt = option auto $ long "lambda" <> short 'l' <> metavar "DOUBLE" <> help "Birth rate lambda" muOpt :: Parser Double muOpt = option auto $ long "mu" <> short 'm' <> metavar "DOUBLE" <> help "Death rate mu" rhoOpt :: Parser Double rhoOpt = option auto $ long "rho" <> short 'r' <> metavar "DOUBLE" <> help "Sampling probability rho" mrca :: Parser TimeSpec mrca = Mrca <$> option auto ( long "mrca" <> metavar "DOUBLE" <> help "Condition on height of most recent common ancestor" ) origin :: Parser TimeSpec origin = Origin <$> option auto ( long "origin" <> metavar "DOUBLE" <> help "Condition on height of origin" ) timeSpec :: Parser TimeSpec timeSpec = fromMaybe Random <$> optional (mrca <|> origin) birthDeath :: Parser Process birthDeath = BirthDeath <$> lambdaOpt <*> muOpt <*> optional rhoOpt <*> timeSpec coalescent :: Parser Process coalescent = pure Coalescent process :: Parser Process process = hsubparser $ ( command "birthdeath" ( info birthDeath ( progDesc "Birth and death process" <> footer "Height: If no tree height is given, the heights will be randomly drawn from the expected distribution given the number of leaves, the birth and the death rate assuming a uniform prior." ) ) <> command "coalescent" (info coalescent (progDesc "Coalescent process")) ) <> metavar "PROCESS" <> commandGroup "Available processes:" subSampleOpt :: Parser (Maybe Double) subSampleOpt = optional $ option auto $ long "sub-sample" <> short 'u' <> metavar "DOUBLE" <> showDefault <> help "Perform sub-sampling; see below." sumStatOpt :: Parser Bool sumStatOpt = switch $ long "summary-statistics" <> short 's' <> showDefault <> help "For each branch, print length and number of children" -- citation :: String -- citation = -- "Gernhard, T. (2008). The conditioned reconstructed process. Journal of Theoretical Biology, 253(4), 769–778. http://doi.org/10.1016/j.jtbi.2008.04.005" -- | And a footer. simulateFooter :: [String] simulateFooter = [ "See, for example, 'tlynx simulate birthdeath --help'.", "Sub-sample with probability p:\n 1. Simulate one big tree with n'=round(n/p), n'>=n, leaves;\n 2. Randomly sample sub trees with n leaves.\n (With p=1.0, the same tree is reported over and over again.)" ]